I did my “little 6” routine today. In payback for a week off, I am now working a lot in the ER and it does have an effect on my recovery. Not so much in my performance, but in how “below the baseline” I feel afterwards. I worked out in the morning, and worked a very busy afternoon shift, and boy could I feel it by the end of the night.

Calf Raise- essentially unchanged weight/TUL
MedX Ab- stable weight/TUL (at my long-term sticking point for this movement)
SS Systems Bicep- decided to use this today. This is Ken Hutchin’s machine with the coupled movement arm and fall-off cam. This was very effective, but a little difficult to coordinate the required body positioning (requires a lot of concentration, especially as you fatigue).
Tricep Pushdown- stable weight/TUL up a couple of seconds
Thick Bar Wrist flexion-stable weight/TUL up 4 seconds
Thick Bar Wrist extension-stable weight/TUL up 6 seconds.

Last Wednesday night I gave a lecture to my clients on hunter-gatherer diets. The turnout was great and the information was well-received. I had it professionally video-recorded and will probably offer this as a DVD for sale (with the handout included). Watch for it in the future. Part of what I discussed was vitamin D3 supplementation. Since I have been supplementing with 4,000-10,000 Units of D3 per day I have noted enhanced recovery and size response from my training. Apparently, skeletal muscle has both surface receptors and nuclear receptors for D3 that augment calcium flux during contraction (from surface receptors) and have steroid-like effects at the nuclear level WRT protein synthesis. This D3 supplementation is not really “supplementation” but is instead “augmentation” to levels that would be normal if we got normal sun exposure as we did in our evolutionary past. Check out www.vitamindcouncil.org for more information. Also, check out this abstract below for your consideration. Also, check out this article.

Biochem Biophys Res Commun. 2001 Dec 21;289(5):1150-6.
The vitamin D receptor mediates rapid changes in muscle protein tyrosine phosphorylation induced by 1,25(OH)(2)D(3).
Buitrago C, Vazquez G, De Boland AR, Boland R.
Departamento de Biología, Bioquímica and Farmacia, Universidad Nacional del Sur., Bahía Blanca, San Juan 670, 8000, Argentina.
It has been recently shown that the fast non-genomic responses of 1,25(OH)(2)-vitamin D(3) [1,25(OH)(2)D(3)] in skeletal muscle cells involve tyrosine phosphorylation of MAP kinase (ERK1/2), c-Src kinase and the oncoprotein c-myc. In the present work, blockade of vitamin D receptor (VDR) expression (> or =80%) by preincubation of chick embryonic muscle cells with three different antisense oligonucleotides against the VDR mRNA (AS-VDR ODNs) significantly reduced (-94%) 1,25(OH)(2)D(3) stimulation of c-myc tyrosine phosphorylation and inhibited c-Src tyrosine dephosphorylation implying lack of c-Src activation by the hormone. Coimmunoprecipitation experiments revealed that 1,25(OH)(2)D(3) induces the formation of complexes between c-Src and c-myc, in agreement with the above results and previous studies showing hormone-dependent association between c-Src and tyrosine phosphorylated VDR and c-Src mediated c-myc tyrosine phosphorylation. MAPK tyrosine phosphorylation by 1,25(OH)(2)D(3) was affected to a lesser extent (-35%) by transfection with AS-VDR ODNs implying that both VDR-dependent and VDR-independent signalling mediate hormone stimulation of MAPK. These are the first results providing direct evidence on the participation of the VDR in non-genomic 1,25(OH)(2)D(3) signal transduction. Activation of tyrosine phosphorylation cascades through this mechanism may contribute to hormone regulation of muscle growth.
PMID: 11741312 [PubMed - indexed for MEDLINE]
Publication Types, MeSH Terms

If you are like me, even the abstract is beyond my comprehension, but the gist of it is in line with something important going on. If you go to pubmed at www.nlm.nih.gov you can also check out the related articles.

Post your WOW’s and your thoughts.

Doug McGuff